Tetracaine hydrochloride CAS No: 136-47-0
Tetracaine hydrochloride CAS No: 136-47-0
Tetracaine hydrochloride ,136-47-0, Tetracaine hydrochloride CAS No: 136-47-0
Product Name: Tetracaine hydrochloride
Product Purity: ≥ 99%
CAS No ：136-47-0
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Description
Tetracaine Hydrochloride Powder (USP/EP)
Premium Local Anesthetic API Manufacturer | High Purity Tetracaine HCl CAS 136-47-0 Supplier
Storage Guidance:
Store in a tightly closed container, protected from light, moisture, and air. Recommended storage temperature is 2-8°C (refrigerated) or cool dry place (below 25°C) to ensure a 24-month optimal shelf life.
Store in a tightly closed container, protected from light, moisture, and air. Recommended storage temperature is 2-8°C (refrigerated) or cool dry place (below 25°C) to ensure a 24-month optimal shelf life.
Product Description & Technical Overview
Tetracaine Hydrochloride (also known as Amethocaine Hydrochloride, CAS 136-47-0) supplied by Shaanxi Sunrise Pharmaceutical Co., Ltd. is a highly potent ester-type local anesthetic API. With its excellent lipophilic properties, Tetracaine HCl offers a rapid onset of action and significantly prolonged anesthetic duration compared to standard lidocaine or procaine.
As a leading raw material supplier, our Tetracaine Hydrochloride powder is synthesized via optimized catalytic pathways under strict GMP guidelines, ensuring extremely low levels of residual solvents and single impurities (≤ 0.1%). It is widely utilized as a key active ingredient in pharmaceutical formulations, including ophthalmic drops, topical anesthetic gels, spinal injections, and mucosal sprays.
| CAS Number | 136-47-0 |
| IUPAC Name | 2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride |
| Molecular Formula | C15H25ClN2O2 (C15H24N2O2 · HCl) |
| Molecular Weight | 300.82 g/mol |
| Assay (Dried Basis) | 99.0% - 101.0% (Conforms to USP/EP) |
| Appearance | White, odorless, crystalline powder (highly hygroscopic) |
| Melting Point | 147°C - 150°C |
| Solubility | Freely soluble in water, soluble in alcohol (96%), insoluble in ether. |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Standard Pack | 1 kg/bag (aluminum foil); 25 kg/cardboard drum |
Why Partner with Shaanxi Sunrise for Bulk Tetracaine HCl?
Rigorous Quality Control & Traceability
Every batch of Tetracaine HCl undergo complete analytical verification, including HPLC, MS, and NMR testing. We guarantee a minimum purity of 99.5%, with individual unknown impurities strictly controlled below 0.1% to meet stringent international monograph requirements.
Optimized Green Synthesis Route
Our chemical synthesis process utilizes highly selective catalysts that maximize yield (>97%) while minimizing hazardous by-products. All manufacturing operations strictly comply with ICH Q3C guidelines for organic residual solvents (free of harmful chlorinated solvents).
Flexible Scale & Custom Mesh Size
From gram-scale evaluation samples for laboratory R&D to multi-ton industrial batches, we provide reliable, scalable supply solutions. Micronization and custom particle size distribution (PSD) from 100 to 500 mesh are available upon request.
Mechanism of Action & Applications
Tetracaine Hydrochloride blocks nerve conduction by reversibly binding to and inhibiting voltage-gated sodium channels (Na+ channels) on the neuronal membrane. This action prevents the transient increase in permeability of the membrane to sodium ions, effectively stabilizing the threshold and blocking action potential propagation.
High Lipophilicity: Tetracaine possesses a highly hydrophobic butyl group on the aromatic ring, yielding superior receptor affinity and deep tissue penetration compared to procaine. This results in an anesthetic potency approximately 10 times higher than procaine.
Ophthalmic Formulations: Widely formulated into 0.5% or 1% ophthalmic drops for rapid ocular surface anesthesia during diagnostic and minor surgical procedures.
Topical and Mucosal Uses: Extensively compounded into local topical creams, sprays, and gels for skin patch procedures, ENT procedures, and dental pain management.
Technical Support, COA & FAQ
Can you provide a COA and HPLC chromatogram before shipping?
Absolutely. Shaanxi Sunrise Pharmaceutical provides a comprehensive Batch Certificate of Analysis (COA) with every shipment. HPLC chromatograms, heavy metal test reports, and MSDS/TDS sheets are fully accessible to our B2B partners upon request.
Does your Tetracaine Hydrochloride comply with USP47 or EP11 standards?
Yes, our API powder is manufactured to fully conform to the latest United States Pharmacopoeia (USP) and European Pharmacopoeia (EP) monographs. We strictly monitor parameters such as heavy metals, loss on drying, residue on ignition, and related organic substances.
What are your shipping methods for global B2B clients?
We offer secure air cargo, sea freight, and reliable express shipping (FedEx/DHL/TNT) with discreet, heavy-duty pharmaceutical-grade vacuum packaging. We are experienced in international customs clearing procedures for raw active ingredients to ensure uninterrupted logistics.
⚠ Safety Warning & Regulatory Declaration
This product is an active pharmaceutical ingredient (API) intended solely for laboratory research, formulation R&D, and commercial manufacturing. Shaanxi Sunrise Pharmaceutical Co., Ltd. does not sell this raw material for direct human or veterinary consumption. All buyers must be qualified pharmaceutical entities, chemical manufacturers, or research institutions.